Психиатрия и психореаниматология

Заголовок темы: Re: агранулоцитоз на оланзапине
Отправитель: Dr.Admin 24.05.2007 23:46:14

Я был не прав, выгораживая оланзапин в этой ситуации. Исправляюсь, смотрим:
-Duggal HS, Gates C, Pathak PC. (2004): Olanzapine-induced neutropenia: mechanism and treatment. J. Clin. Psychopharmacol. 24, 234-235
-Imbarlina MJ, Sarkar S, Marwah S, Parepally H, Johnston PR, Brar JS, Chengappa KN. (2004): Leukopenia in clozapine treated patients may be induced by other drugs: a case series. Eur. Psychiatry 19, 506-509

Работ по теме не так много, вот например:
Цитата:

Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):958-9. Epub 2006 Apr 24. Links
Prolongation of clozapine-induced leukopenia with olanzapine treatment.Sayin A, Cosar B.
Department of Psychiatry, Gazi University Medical School, Turkey. aslihansayin@yahoo.com
Clozapine is a well-known antipsychotic to cause fatal agranulocytosis but there are only a few case reports about the risk of leukopenia and agranulocytosis associated with other atypical antipsychotics. Olanzapine has structural pharmacological similarities to those of clozapine and reports about haematological adverse effects of olanzapine include three groups: the first group includes cases of olanzapine-induced neutropenia, the second informing that olanzapine is safe after clozapine induced agranulocytosis and the third group forms prolongation of clozapine-induced leukopenia with olanzapine use. The aim of this paper is to report a case of prolongation of clozapine-induced leukopenia despite olanzapine treatment and discuss leukopenia caused by atypical antipsychotic use in the light of recent and limited literature.

...
По аналогии с азалептином, риск подобных дел высок в первое время приема, и к концу первого года приема составляет крайне незначительные величины, но ухо нужно держать востро.