DISC1 expression in tissue

Studies at the RNA and protein level have revealed that DISC1 is expressed in many adult and foetal human tissues including the heart, brain, placenta, kidney and pancreas.9, 65 DISC1 transcripts are most abundantly expressed in placenta, heart and brain.9 Heart is also a highly expressing tissue in adult rodents with additional expression documented in brain, kidney, liver and testis.55, 56

immunostaining of mouse brain sections revealed dysbindin confined to neurons, with no significant labeling of glial cells. Dysbindin localized primarily in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus.